Question of the Week

Question :

Posted On : 20 Feb 2006

Can you please tell me the features of pseudolymhoma syndrome caused by prolonged use of phenytoin? Will it produce hepato- splenomegaly along with generalised lymphadenopathy?

Expert Answer :

No expert answer available.

Answer Discussion :

dr.yogesh

It is a rare type of idiosyncratic reaction seen,presenting mainly with painless Lymphadenopathy,almost never associated with Hepatosplenomegaly

19 years ago

Dr Manorma Gadde

19 years ago

Dr T A Khan

Generalised lymphadenopathy may be seen after prolonged use of phenytoin but hepatospleenomegaly is not usual

19 years ago

pediatriconcall

Patients receiving phenytoin may develop pseudolymphoma or, rarely, malignant lymphoma and mycosis-fungoides-like lesions in the inguinal or cervical region.
Most patients present with a single, slowly enlarging, papular, nodular, or plaquelike lesion several weeks following the initiation of anticonvulsant medications. However, several patients have demonstrated drug-induced pseudolymphoma after more than 5 years of therapy.
Immunophenotyping of the lymphoma is essential to make the daignosis. Most drug-induced pseudolymphomas contain CD3 Plus CD4 Plus T cells
Other physical findings may include splenomegaly, marked localized or diffuse lymphadenopathy, and high-grade fever.

19 years ago

Dr Manorma Gadde

19 years ago

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