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Pediatric TB is hard to catch: low bacterial load, children who can’t produce sputum, and non-specific symptoms mean many cases are missed. In 2023, about 1.2 million children under 15 fell ill with TB, and an estimated 226,000 died. In this lecture, Dr. Ira Shah (Professor & Head, Pediatric Infectious Diseases, B.J. Wadia Hospital for Children, Mumbai) reviews the newer diagnostic tools that can make pediatric TB diagnosis faster, more accurate, and more child-friendly.
The session covers the full modality landscape: Xpert MTB/RIF Ultra, Truenat, the Xpert XDR panel, line probe assays, near-point-of-care NAATs, urine LF-LAM, sample selection (sputum, gastric aspirate, NPA, stool), liquid culture and MODS, blood biomarkers, latent TB tests (QFT-Gold vs Gold Plus), and whole-genome sequencing. It also includes the institution’s own data on stool Xpert in 52 children, guidance on choosing the right test in practice, implementation challenges, and future research directions such as Xpert MTB Host Response.
Video Chapters include:
00:00 Intro
00:18 The Diagnostic Gap
01:17 TB has come a long way...
01:40 The Modality Landscape
03:07 Xpert MTB/RIF Ultra
04:21 Truenet
05:31 Comparisson
05:54 Xpert XDR Panel
06:41 Diagnosis of TB
07:16 Line Probe Assays
07:52 NPOC-NAATs
08:23 LF-LAM
09:35 Samples
11:05 Our data
11:35 Culture based Methods
12:37 MODS
13:17 Evidence Review
13:41 Biomaker blood tests
14:38 Latent TB-Diagnostic Tests
15:06 QFT-Gold vs Gold plus
15:44 whole Genome Sequencing
16:33 Direct comparisson
17:25 How the Modalities compare
18:14 Choosing the right test in practise
19:53 Implementation Challenges
20:48 Future Directions & Research priorities
21:30 Xpert MTB Host Response
22:03 Key takeaways
Read more about:
Management of Pediatric TBM 2026 – Where Are We?: https://youtu.be/gu2XZzCQoZo?si=M4Bv5mc_OdnbJwii
Pediatric Tuberculosis – Unpacking challenges and Spotlighting What’s New: https://youtu.be/GYsMnsg9lvw?si=PUEZ4DnpbGelwOTH
#PediatricTB #TBDiagnosis #XpertUltra #Truenat #ChildhoodTB #Tuberculosis #PediatricInfectiousDisease #StoolXpert #DrugResistantTB #LFLAM #WholeGenomeSequencing #DrIraShah #EndTB #MedicalEducation #CME
PEDIATRIC ONCALL is the Web's most robust and integrated medical information and education tool with an extensive network of doctors as registered members.
2026-10-15
Newer Diagnostic Modalities in Pediatric Tuberculosis: What’s New in Detecting TB in Children?
Description
Pediatric TB is hard to catch: low bacterial load, children who can’t produce sputum, and non-specific symptoms mean many cases are missed. In 2023, about 1.2 million children under 15 fell ill with TB, and an estimated 226,000 died. In this lecture, Dr. Ira Shah (Professor & Head, Pediatric Infectious Diseases, B.J. Wadia Hospital for Children, Mumbai) reviews the newer diagnostic tools that can make pediatric TB diagnosis faster, more accurate, and more child-friendly.
The session covers the full modality landscape: Xpert MTB/RIF Ultra, Truenat, the Xpert XDR panel, line probe assays, near-point-of-care NAATs, urine LF-LAM, sample selection (sputum, gastric aspirate, NPA, stool), liquid culture and MODS, blood biomarkers, latent TB tests (QFT-Gold vs Gold Plus), and whole-genome sequencing. It also includes the institution’s own data on stool Xpert in 52 children, guidance on choosing the right test in practice, implementation challenges, and future research directions such as Xpert MTB Host Response.
Video Chapters include:
00:00 Intro
00:18 The Diagnostic Gap
01:17 TB has come a long way...
01:40 The Modality Landscape
03:07 Xpert MTB/RIF Ultra
04:21 Truenet
05:31 Comparisson
05:54 Xpert XDR Panel
06:41 Diagnosis of TB
07:16 Line Probe Assays
07:52 NPOC-NAATs
08:23 LF-LAM
09:35 Samples
11:05 Our data
11:35 Culture based Methods
12:37 MODS
13:17 Evidence Review
13:41 Biomaker blood tests
14:38 Latent TB-Diagnostic Tests
15:06 QFT-Gold vs Gold plus
15:44 whole Genome Sequencing
16:33 Direct comparisson
17:25 How the Modalities compare
18:14 Choosing the right test in practise
19:53 Implementation Challenges
20:48 Future Directions & Research priorities
21:30 Xpert MTB Host Response
22:03 Key takeaways
Read more about:
Management of Pediatric TBM 2026 – Where Are We?: https://youtu.be/gu2XZzCQoZo?si=M4Bv5mc_OdnbJwii
Pediatric Tuberculosis – Unpacking challenges and Spotlighting What’s New: https://youtu.be/GYsMnsg9lvw?si=PUEZ4DnpbGelwOTH
#PediatricTB #TBDiagnosis #XpertUltra #Truenat #ChildhoodTB #Tuberculosis #PediatricInfectiousDisease #StoolXpert #DrugResistantTB #LFLAM #WholeGenomeSequencing #DrIraShah #EndTB #MedicalEducation #CME
PEDIATRIC ONCALL is the Web's most robust and integrated medical information and education tool with an extensive network of doctors as registered members.