Question of the Week

Question :

Posted On : 15 Aug 2006

Can "Cefepime" be used in the treatment of meningitis and osteomyelitis?

Expert Answer :

No expert answer available.

Answer Discussion :

mohamed nael

yes it can be used

18 years ago

khadija qureshi

yes

18 years ago

Piotr Sawiec

yes

18 years ago

El-Sayed Mohammed Ayoub Rakha

18 years ago

pediatriconcall

Though there have been reports of use of cefipime for treatment
of meningitis in adults, Cefepime is approved by FDA as empiric
monotherapy for febrile neutropenic patients. Its additional indications
include hospital-acquired pneumonia and urinary tract infections due to
susceptible Gram-negative pathogens, uncomplicated skin and
skin-structure infections, and complicated intra-abdominal infections
{when used with metronidazole, with or without ampicillin}. Cefepime is
not indicated, however, for treatment of meningitis.

Multicenter clinical data in the pediatric population Cefepime
concentrations in CSF ranged from 5.7 micrograms-mL 0.5 hours after the
first dose to 3.3 micrograms-mL 8 hours after that initial dose. These
values represent 12 percent and 117 percent of concentrations in serum,
respectively, and exceeded the minimum inhibitory concentrations {MIC}
of the patients' pathogens, most commonly type b Hemophilus influenzae
and Neisseria meningitidis, many times over.

References:

Pharmacokinet. 1993,25:88-102. Saez-Llorens X, Castano E, Garcia R, et
al. Prospective randomized comparison of cefepime and cefotaxime for
treatment of bacterial meningitis in infants and children. Antimicrob
Agents Chemother. 1995,39:937-940.

18 years ago

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