Question of the Week

Question :

Posted On : 19 Nov 2005

The half life of Dexamethasone is 24 hours, then why we are giving it six hourly in treatment of bacterial meningitis?

Expert Answer :

No expert answer available.

Answer Discussion :

Enrique Finetti

because the minimal concentracio must be stable

19 years ago

DR.SYED KASHIF ABBAS

BECAUSE PERTICULAR LEVEL IS REQUIRED TO INHIBIT SYNTHESIS OF CYTOKINE

19 years ago

meenal lakshmanan

to reduce intra cranial hypertension and reduc ethe risk from fibrous reaction post inflammation

19 years ago

pediatriconcall

Dexamethasone has been recommended as adjunctive therapy in children with bacterial meningitis, because the drug significantly reduces inflammation in the central nervous system {CNS}. Clinical and laboratory abnormalities resolve more quickly and long-term neurologic sequelae are reduced in infants and children who receive dexamethasone, compared with children who receive placebo. Adverse effects of dexamethasone in children with bacterial meningitis have been limited mainly to gastrointestinal bleeding.
Injections of dexamethasone give maximum plasma concentrations of dexamethasone at 1 hour. The biological half-life of dexamethasone is about 190 minutes.

19 years ago

dr.s-halloush

to get higher serum level as the course it self is short {3-4}days so ot decrese the effect of cell lysis of the invasive bacteria

19 years ago

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