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Question :

Posted On : 11 Apr 2005

Now it has been recomended that in kawasaki disease the antinflammatory dose of Aspirin been reduced to 50mg,kg,day in 4 divided doses,almost half of the dose that we have been using so far.Has anyone tried this and is the effect and outcome similar? thank you.

Expert Answer :

No expert answer available.

Answer Discussion :

Dr. V G Chaudhari

20 years ago

jayamt daikwad

no tried

20 years ago

pediatriconcall

Although aspirin is part of standard therapy in KD because of its anti-inflammatory, antipyretic, and antiplatelet effects, no prospective study has shown that aspirin at any dose reduces the incidence of CAAs. A US clinical trial by Melish18 compared IVIG 2 g-kg plus high-dose {100 mg-kg per day} aspirin with IVIG plus low-dose {3–8 mg-kg per day} aspirin and found that there was no significant difference between the two groups in the incidence of CAAs. A meta-analysis by Durongpisitkul et al19 demonstrated that high-dose {2 g-kg} IVIG therapy plus high-dose { More than 80 mg-kg} or lower-dose { Less than 80 mg-kg} aspirin regimen was associated with a similar incidence of CAAs after disease onset {4.8 Percent vs 4.0 Percent}.

Ref: PEDIATRICS Vol. 114 No. 6 December 2004

However, further studies are required to determine whether aspirin is required or not in treatment of Kawasaki's disease.

20 years ago

abdulkhaliq

i have no idea

20 years ago

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