Question of the Week

Question :

Posted On : 05 Dec 2006

Is Vit C therapy contraindicated in thalassemic patients on desferal with cardiomyopathy in failure?

Expert Answer :

No expert answer available.

Answer Discussion :

sangeeta kumar

18 years ago

shilpa

18 years ago

B P Srivastav

18 years ago

B P Srivastav

18 years ago

samir

no you can give vit C
Ascorbic acid deficiency increases insoluble iron {hemosiderin}. Vitamin C helps in conversion of hemosiderin into ferritin from which iron can be chelated.

* High doses of Vitamin C can lead to increased free radical reaction and lipid peroxidaton resulting in tissue damage and rapid cardiac decompensation and even death. Addition of vitamin C 100 mg daily prior to DFO therapy increases iron excretion. 60 Percent of DFO chelated iron is excreted in urine, and 40 Percent in stool.

18 years ago

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