Question of the Week

Question :

Posted On : 27 Oct 2008

Is it good to use Cefixime clavulanic acid combination? How far it is successful in enteric fever and uti?

Expert Answer :

No expert answer available.

Answer Discussion :

Ronald Eveillard

Yes. 90 Percent

16 years ago

pediatriconcall

Cefixime and clavulanic acid can be used as a second line therapy where cefixime alone is not able to show it's bacteriocidal activity. Cefixime comes under beta lactum antibiotic category and gets degrade inpresence of beta lactumase enzyme, bacterias have developed resistance against cefixime by producing beta lactamase and ESBLs. Clavulanic acid is an irreversible inhibitor of beta lactamase enzyme and have mild antibiotic activity. when this combination is used, clavulanic acid inhibits beta lactamase enzyme and allow cefixime work as a bacteriocidal.
The combination is very useful against cefixime resistant becteria. More research work is required to understand the further use of this combination and also to find out the superiority of this combination over AmoxiClav combination.

16 years ago

Sajjad Hussain

Dont know

16 years ago

dr-hosam shaban

good treatment

16 years ago

usama morid

yes it can be useful

16 years ago

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