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Posted On : 30 Jun 2010

how to lab work for criggler najjar syndrme_?_?

Expert Answer :

Answer Discussion :

R

Rajendra Arakere

0

GEnetic work up

15 years ago

F

fatma othman

0

high total and direct bilirubin,normal retic. count, closed liver biobsy for glucoronyl transeferase activity,DNA studies for child and parents

15 years ago

N

navdeep saini

0

total and direct bilirubin,and ruling out other causes of jaundice , and response to phenobarbitone

15 years ago

N

navdeep saini

0

total and direct bilirubin,and ruling out other causes of jaundice , and response to phenobarbitone

15 years ago

R

raj mohan

0

udpgt

15 years ago

Answer 1

Unconjugated hyperbilirubinemia in the presence of normal liver function test findings ruling out all other causes of indirect hyperbilirubinemia is characteristic of Grigler Najjar syndrome. Transferase activity measurements and the response to Phenobarbital treatment distinguish type 1 from type 2.

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