Discussion :
Children with acute lymphoblastic leukemia {ALL} frequently present with hepatomegaly and mild liver functional impairment. Severe jaundice is a rare complication of leukemia. Jaundice could be due to liver damage due to drugs, viral infections, tumour cell infiltrations and hemolysis. In this child, since viral markers were negative and the child already had jaundice prior to start of chemotherapy, the most likely cause of jaundice in this patient is leukemic infiltration of the hepatic sinusoids. Since this child had thrombocytopenia, a transjugular liver biopsy was done and histopathology showed leukemic infiltration of the liver.
E-published: January-March 2014 Vol 11 Issue 1 Art No. 5
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