Bisacodyl
Mechanism :
Bisacodyl is a stimulant laxative. Bisacodyl stimulates the smooth muscle of the intestines. This causes the normal peristalsis. It increases water in the intestines, resulting in a bowel movement.
Indication :
Contraindications :
In intestinal obstruction and in case of any undiagnosed acute or persistent abdominal symptoms.
Dosing :
6-12 years: 5 mg or 0.3 mg/kg PO at bedtime or before breakfast.
>12 years: 5-15 mg orally at bedtime.
Adverse Effect :
Griping, excessive diarrhea, nausea, vertigo, vomiting. Prolonged use may lead to an atonic non-functioning colon and hyperkalemia.
Interaction :
Antacids: Should not be given within 1 hour of administering bisacodyl.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Unlikely to be dialysed. Dose as in normal renal function |
| HD | Unlikely to be dialysed. Dose as in normal renal function |
| HDF/High flux | Unlikely to be dialysed. Dose as in normal renal function |
| CAV/VVHD | Unlikely to be dialysed. Dose as in normal renal function |
Hepatic Dose :
No dosage adjustments are recommended.