Sorbitol
Mechanism :
It is a sugar that occurs naturally in fruits and vegetables and is used as a sweetening agent especially in the case of diabetic foods. It is also used in the treatment of constipation.
Indication :
Contraindications :
Acute abdominal pain, nausea, vomiting, or other symptoms of appendicitis or undiagnosed abdominal pain.
Dosing :
<2 years:
Safety and efficacy not established.
2-11 years:
Oral: 2 mL/kg (as 70% solution) once.
Rectal enema:
30-60 mL as 25-30% solution.
>12 years:
Oral: 30-150 mL (70% solution) once.
Rectal enema:
120 mL of 25-30% solution once.
Adverse Effect :
Diarrhea, dehydration, electrolyte losses, hyperglycemia, lactic acidosis, vomiting.
Interaction :
Sodium Polystyrene Sultanate: Combination is implicated in colonic necrosis.
Hepatic Dose :
No dose adjustment recommended.