Question of the Week

Question :

Posted On : 27 Aug 2008

What is dosage schedule of Methyl Prednisolone IV as pulse therapy in Nephrotic syndrome?

Expert Answer :

No expert answer available.

Answer Discussion :

waleedmb sabry

2mg,kg,d

16 years ago

Dr Vinayak ramrao Deshmukh

500mg. on alternate days 3doses.

16 years ago

pediatriconcall

There are no controlled studies in children looking at proper dosing of steroids {oral, IV, etc} for nephrotic syndrome. The ISKDS years ago looked at 2 mg per kg per day of steroids {orally} divided TID for new onset NS and that has become the standard of care.
Many nephrologists, if concerned that the patient will not be a routine NS, will often `pulse` the patient with 5-10 mg per kg per dose for 2-3 days {not to exceed a gm per day} of solumedrol for severe diseases. Examples of this would include renal involvement {e.g. NS} with Wegener`s, Lupus, systemic vasculitis or even steroid resistant NS {e.g. Mednoza protocol}.
IV solumedrol should be reserved for non routine NS and in my opinion has little role in standard childhood NS.

Dr Timothy Bunchman
Professor Pediatric Nephrology and Transplantation
Helen DeVos Children`s Hospital
USA

16 years ago

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