Question of the Week

Question :

Posted On : 08 Sep 2007

What are indications of PAM in organophosphorus poisoning?

Expert Answer :

No expert answer available.

Answer Discussion :

pediatriconcall

PAM is used as an antidote to reverse muscle paralysis as it reactivates the phosphorylated AChE by binding to the OPC. It is ineffective once the OPC has bound AChE irreversibly and hence needs to be administered within 48 hours of exposure. Dose recommended is 20-40 mg-kg IV in 100 ml NS-D5 over 15-30 min to be repeated in 1-2 hours if muscle weakness is not relieved. PAM can precipitate myasthenia gravis and muscle rigidity in healthy volunteers.

17 years ago

saeedelsadek

for heavy exposure, where atropine seems to be insufficient,pupils fail to react

17 years ago

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