Question of the Week

Question :

Posted On : 05 Apr 2006

Is it safe to use the inactivated vaccine for JE currently available? where is the cell derived vaccine available?

Expert Answer :

No expert answer available.

Answer Discussion :

nikhil agrawal

The currently available vaccine for JE is inactivated and mouse brain derived and is given over 1 year of age at 0,7,30 days with booster at 1 and 3 years. It may cause serious anaphylactic reactions in some patients who are allergic. Cell derived vaccine is also inactivated and is grown on hamsters kidney cells, it is available in China and Nepal.
A live vaccine is also available in China which is very effective with least side effects.

19 years ago

pediatriconcall

Answer: The currently available JE vaccine is a killed mouse brain vaccine derived from Nakayama strain and is imported from Korea.In India the same vaccine is manufactured in Central Research Institute,Kasauli,Himachal Pradesh and is supplied to State Govts on demand.This is not available for sale in private market.This vaccine is relatively safe and has an efficacy of about 80 Percent.However occasional complications in the form of myelitis is reported.
The live attenuated vaccine is manufactured only in China and has been found to be safe and more efficacious with almost 100 Percentseroconversion.At present it is used only for Chinese market.However the vaccine is shortly going to be marketed by a Koren company.It will take sometime for this vaccine to come to India since the vaccine is not WHO certified and a bridging clinical seroconversion study will be required before the vaccine marketed in India.

19 years ago

tamer gaber