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Posted On : 20 Apr 2025

How much dilution of Ceftriaxone and mikacin is recommended? We are giving Ceftriaxone 1 gm in 100 ml ns. Can we give it in routine RL or DNS or isolyte p 500 ml drip? We are giving Mikacin without dilution. What are your recommendations?

Expert Answer :

Answer Discussion :

A

Abdalla Almatbagi

0

Ceftriaxone can diluted in 100 mlNS Or inDN S Amikacin can be diluted in 5 ml of N S. R L is not used

3 Days ago

D

Dr Kathy Davis Davis

1

depends on infection or injection recommend

6 Days ago

J

JIGNESH KACHARIYA

2

We give ceftriaxone in dilution in 100ml NS, amikacin in 5ml NS dilution.

but wondering why option provided for ISOLYTE-P, (Hypo-osmolar)
isn't it is banned as IV fluid in pediatrics age group ?

6 Days ago

A

Arathi Chandran

1

Its ideal to give Ceftriaxone in dilution to a max final concentration not exceeding 40mg/ml.Not to use Ringer lactate or Any Calcium containing fluids for diluting Ceftriaxone. Calcium precipitates Ceftriaxone
Amikacin should be ideally diluted to a concentration not exceeding 15mg/ml.
Always choose the amount of diluent keeping in mind the age, weight& Child's total intake, no.of IV drugs

6 Days ago

D

DrAhemad Pothiawala

0

I am giving injection ceftrioxone either in 100 ml ns or 500 ml ns or dns never in RL or isolyte p, amilacin 100mg in 5ml of dw iv slowly in iv fluid & without dilution im

6 Days ago

Answer 1

Do not use diluents containing calcium, such as Ringer’s solution or Hartmann’s solution, to reconstitute ceftriaxone. It should be administered intravenously by infusion over a period of 30 minutes. Concentrations between 10 mg/mL and 40 mg/mL are recommended. It is stable for 24 hours at room temperature only in 0.9 percent sodium chloride injection or 5 percent Dextrose in water (D5W).

Usual diluent for Amikacin is NS, D5W. Amikacin sulfate is stable for 24 hours at room temperature and 2 days at refrigeration at concentrations of 0.25 and 5.0 mg, mL in the following solutions:
5% Dextrose Injection, USP
5% Dextrose and 0.2 percent Sodium Chloride Injection, USP
5% Dextrose and 0.45 percent Sodium Chloride Injection, USP
0.9% Sodium Chloride Injection, USP
Lactated Ringer’s Injection, USP

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