Desonide
Mechanism :
Desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Indication :
Contraindications :
Contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.
Dosing :
Available as 0.05% w/w cream.
Applied to the affected areas as a thin film two or three times daily.
Adverse Effect :
Contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.
Stinging and burning, irritation, contact dermatitis, peeling of skin, itching, intense transient erythema, dryness/scaliness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae and miliaria, systemic steroid toxicity.
Hepatic Dose :
No dosage adjustments are recommended.