Desloratadine
Mechanism :
Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.
Indication :
- Allergic rhinitis
- Urticaria
Contraindications :
Contraindicated in patients who are hypersensitive to this medication or to any of its ingredients, or to loratadine.
Dosing :
Under 6 months:
Safety and efficacy not established.
6-12 months:
1 mg; orally once daily.
1-5 years:
1.25 mg; orally once daily.
6-11 years:
2.5 mg; orally once daily.
12-18 years:
5 mg orally once daily.
Adverse Effect :
Tachycardia, edema, somnolence, fatigue, dizziness, nausea, elevated liver enzymes.
Interaction :
Additive CNS depressant: effect with other CNS depressants and alcohol.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Not dialysed. Dose as in normal renal function |
| HD | Not dialysed. Dose as in normal renal function |
| HDF/High flux | Unknown dialysability. Dose as in normal renal function |
| CAV/VVHD | Unlikely to be dialysed. Dose as in normal renal function |
Hepatic Dose :
Dosage interval adjustment may be necessary and dose intervals may have to be increased.