Home
Submit New Manuscript
Manuscripts in Draft (
0
)
Pending Revisions (
0
)
Manuscripts in Review (
0
)
Accepted Manuscripts (
0
)
Rejected Manuscripts (
0
)
Manuscripts in Review (
0
)
Co-Author History (
0
)
Home
Pending Review (
0
)
Expired/Declined (
0
)
Accepted Manuscripts (
0
)
Rejected Manuscripts (
0
)
Menu
Disease
A-Z
Health Topics
Alternative Medicine
Developmental Pediatrics
General Pediatrics
Genetics
Immunodeficiencies
Infectious Diseases
Laboratory Medicine
Neonatology
Nutrition
Pediatric Cardiology
View all Topics
Featured Articles
Anal itching
Hypospadias
Cushing's syndrome
Skin allergies
Urticaria (hives) and angioedema
Diabetic ketoacidosis
Kids Corner
Health and Knowledge with fun.
Drugs &
Calculators
Medical Calculators
Drug Calculators
Genetic Calculators
Growth Calculators
View all Calcualtors
Drug Index
ACE inhibitor
Alkylating agents
Allergies
View all Drugs
Poisoning Center
Aluminum phosphide
Anti-histaminics
Antidepressants
View all Drugs
Medical Eqipments
Monitors
Pumps
Incubators
View all Equipments
Diagnostic Aid
Get your diffrential
diagnosis.
Consult
& Posts
Ask a Doctor
Diagnostic Dilemma
Question of the Week
Pediatric Blogs
Spot Diagnosis
Grand Rounds
Pedi Poll
Pediatric
Journal
Current Issue
All Issues
Advance Access
About the Journal
Submit Article
Books
& Apps
Book Store
Pediatric Oncall
Medical Calculators
Vaccine Reminder
Pediatric Oncall Journal
Drug Center
Parenting
CME &
Videos
Upcoming Conferences
Conference Abstracts
MCQs
Videos
Vaccine
Reminder
Sign In
Conference Abstract
›
National Medical Students Paediatric Conference (NMSPC) 2014, Brighton, UK
›
Retrospective Clinical Audit: The long-term sequelae of the combined treatment (surgery, radiotherapy and chemotherapy) for medulloblastoma in children and its profound effect on the quality of life in survivors.
Retrospective Clinical Audit: The long-term sequelae of the combined treatment (surgery, radiotherapy and chemotherapy) for medulloblastoma in children and its profound effect on the quality of life in survivors.
Hanin Tawfik*
University of Liverpool, UK*
Abstract
Background:
Medulloblastoma, primitive neuroectodermal tumor (PNET), is the second most common brain tumour in childhood. Accounting for about 20% of central nervous system tumours and 40% of all posterior fossa tumours in children, between the ages of 1 and 9 (1, 2). The tumor is more common in males than females (3). Treatment consists of a combined approach that includes surgery, radiotherapy and chemotherapy (4).
Aims:
To investigate the possible late-effects followingthe combined treatment for medulloblastoma in children. And to explore to what degree it can reduce the quality of life in the long-term survivors.
Methods:
A review of the literature was undertaken on databases such as SCOPUS and PubMed. The retrospective audit consisted of collecting data from medical records of 22 histologically confirmed medulloblastoma from 1984 to 2010 with average age 9 years and 2 monthsat time of diagnosis at the Clatterbridge oncology centre.
Results:
The children who received chemotherapy in addition to radiotherapy had lower scores on the quality of-life assessment than did those who received radiotherapy alone (5), and lower overall score on the Health Utility Index in a 7 year follow-up study (6).
The audit main findings were that all children who had undergone the combined treatment would experience acute and late effects. Overall, 22 cases out of which there were 15 boys and 7 girls, 59.1% experienced pituitary dysfunction (growth hormone deficiency) and 40.9% were diagnosed with second malignancies.
Conclusion:
The aggressive treatment modalities leads to a greater survival but with this greater increase in survival comes the potential for a long-term unwanted effects such as physical and functional disabilities, or endocrine dysfunction (7).
New therapeutic agents are being tested for safety and efficacy. Yet, a great deal of work remains to be done to effect reliable therapies while reducing long-term sequelae (8).
References :
Eric K. Hansen MRI. Handbook of evidence- based radiation oncology: Springer; 2007.
Books B. evidence-based paediatric oncology: blackwell publishing; 2007.
Singer M. The epidemiology of brain tumours in children. accessed 01/02/2012. Available from: http://www.childhoodbraintumor.org/THE%20EPIDEMIOLOGY%20OF%20BRAIN%20TUMORS_Part%201.pdf.
Tidy DC. Brain Tumours in Children [accessed 01/02/2012]. Available from: http://www.patient.co.uk/doctor/Brain-Tumours-in-Children.htm.
Roger J. Packer GV. Management and prognosis with medulloblastoma. Arch Neuroal. 2008; 65:1419-1124.
Packer RJ. Reduction of health status 7 years after addition of chemotherapy to cranio-spinal irradiation for medulloblastoma: a follow-up study on PNET-3 trial survivors. Curr Neurol Neurosci Rep. 2008;8:111-113.
Silverman CL, Palkes H, Talent B, Kovnar E, Clouse JW, Thomas PR. Late effects of radiotherapy on patients with cerebellar medulloblastoma. Cancer. 1984;54:825-829.
Rood BR, Macdonald TJ, Packer RJ. Current treatment of medulloblastoma: recent advances and future challenges. Semin Oncol. 2004;31:666-675
DOI: 10.7199/ped.oncall.2014.
How to Cite URL :
Tawfik H.. Available From : http://www.pediatriconcall.com/conference/abstract/33/view/824
Conference Abstract List
The prevalence of developmental disorders in Looked after Children in Sheffield compared to the general population.
A Systematic Review Considering the Use of Cuffed vs Uncuffed Endotracheal Tubes in Children
A Literature Review of Current Management of Patent Ductus Arteriosus in Neonates
How does the experience upon the parents of surgical patients on the Royal Alexandra Children’s Hospital HDU differ to those on other wards?
Retrospective Clinical Audit: The long-term sequelae of the combined treatment (surgery, radiotherapy and chemotherapy) for medulloblastoma in children and its profound effect on the quality of life in survivors.
Detection and Treatment of Tuberculosis Infection in Children in Brighton: A Service Evaluation
A Public Health Problem: Management of Thalassemia in Malaysia
Effectiveness of Total Parenteral Nutrition in Infants’ Growth
Pediatric Difficult Airway Equipment in Emergency Departments: A regional audit
Ask a Doctor
Book Store
Infection in Children - Part 2
Order Now
Recommended for you
Wilson's Disease
Igg Subclass Deficiency
Brain Malformations
Calculators
Serum Ascites Albumin Gradient(SAAG)
Paediatric Crohn’s Disease Activity Index
Arterial Blood Gas (ABG) Calculator
Hyperbilirubinemia Risk Nomogram
Acetaminophen Toxicity Nomogram
Videos
Difficult to Treat TB in child | Pediatric Case Study
Pediatric Specialist Shares Top Mycobacterial Infection Tips #Pediatriconcall #Pediatrics #Case #TB
Neonatal Cholestasis
View All
MCQ
MCQs Set 3
MCQs Set 1
MCQs - Hematology and Immunology
MCQS ON PEDIATRIC EMERGENCIES
MCQs on Infectious Diseases - 2
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
X
Sign In
Disease A-Z
Health Topics
Alternative Medicine
Developmental Pediatrics
General Pediatrics
Genetics
Immunodeficiencies
Infectious Diseases
Laboratory Medicine
Neonatology
Nutrition
Pediatric Cardiology
View all topics
Featured Articles
Anal itching
Hypospadias
Cushing's syndrome
Skin allergies
Urticaria (hives) and angioedema
Diabetic ketoacidosis
Kids Corner
Drugs & Calculators
Medical Calculators
Drug Calculators
Genetic Calculators
Growth Calculators
View all Calculators
Drug Index
ACE inhibitor
Alkylating agents
Allergies
View all Drugs
Poisoning Center
Aluminum phosphide
Anti-histaminics
Antidepressants
View all Drugs
Medical Eqipments
Monitors
Pumps
Incubators
View all Eqipments
Diagnostic Aid
Consult & Posts
Ask a Doctor
Diagnostic Dilemma
Question of the Week
Pediatric Blogs
Spot Diagnosis
Grand Rounds
Pedi Poll
Pediatric Oncall Journal
Current Issue
All Issues
Advance Access
About the Journal
Submit Article
Books & Apps
Book Store
Pediatric Oncall
Medical Calculators
Vaccine Reminder
Pediatric Oncall Journal
Drug Center
Parenting
CME & Videos
Upcoming Conferences
Conference Abstracts
MCQs
Videos
Vaccine Reminder
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0