Abstract
The present study aims to understand if there is a significant difference between the value of CK between children with and without an IMD; to compare the probability of recurrence between the two groups; to compare the main triggers of CK elevation and to establish a CK value as a cut-off for suspecting of an IMD.
We performed a cross-sectional study. We divide our sample in two groups: group 1 – the ones with an IMD; group 2 – the ones without an IMD. The following variables were studied: age, sex, trigger for CK increase, place of CK measurement, CK value and occurrence of recurrence.
A total of 138 patients were included, 7 with an IMD and 131 without. We found 198 cases of CK > 1000 IU/L, 55 in the first group and 143 in the second. The 7 patients in the first group had an IMD involving energy metabolism. In the group with an IMD, the CK presented a median of 11769 IU/L and in the second group of 2167 IU/L with a statistically significant difference (p < 0.001). We conclude that there is an association between having an IMD and the recurrence of CK > 1000 IU/L (p<0.001). The optimal value of CK of 2709 IU/L was found to predict when one should suspect of an IMD.
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