Tinidazole

Mechanism :

Tinidazole is an anti-infective drug used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. It is responsible for disrupting the DNA helical structure, thus inhibiting nucleic acid synthesis.

Indication :

• Amoebiasis
• Giardiasis
• Trichomonas Vaginalis

Contraindications :

Contraindicated in patients with a prior history of hypersensitivity to tinidazole or other nitroimidazole derivatives and during the first trimester of pregnancy. Use with caution and reduce dose in severe hepatic Impairment.

Dosing :

Adverse Effect :

Nausea, vomiting, unpleasant taste, darkening of urine, drowsiness, dizziness, headache and ataxia, weakness/fatigue/malaise, skin rashes, urticaria, myalgia and arthralgia. During intensive or prolonged therapy, seizures or peripheral neuropathy have occurred. Mild leukopenia and thrombocytopenia have also been reported rarely.

Interaction :

Warfarin: Potentiates anticoagulant effects.
Lithium: Increased levels of lithium may lead to lithium toxicity.
Phenytoin: Increased levels may occur, and levels should be monitored.
Cimetidine: Reduces hepatic metabolism, leading to increased serum levels and potentially increased incidence of side-effects.
Phenobarbital: May significantly decrease serum levels.
Disulfiram: Reaction may occur with alcohol and the alcohol content of concurrently administered medication should be considered.

Renal Dose :

Hepatic Dose :