Menthol Camphor
Mechanism :
Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.
Camphor is mild topical analgesic and antipruritic.
Indication :
- Mild muscle and joint pain
Contraindications :
Children below 2 years.
Dosing :
>12 years: Apply to affected area 3-4 times a day. Massage until thoroughly absorbed into skin.
Adverse Effect :
Children below 2 years.
Severe allergic reactions (rash; itching; hives; tightness in the chest; difficulty breathing; swelling of the lips, mouth, face, or tongue); severe irritation at the application site.
Hepatic Dose :
No dosage adjustments are recommended.