Dehydroemetine
Mechanism :
It is an antiamoebic agent used in the treatment of intestinal and hepatic amoebiasis. It acts by inhibiting protein synthesis by arresting intra ribosomal translocation of tRNA-amino acid complex. Kills trophozoites but ineffective against cysts. It is available in both tablet and injectable preparations and is less toxic as compared to emetine.
Indication :
- Acute amoebic dysentery
- Amoebic liver abscess
- Liver fluke infestation
Dosing :
0.75-1 mg/kg/day in 2 divided doses IM for 5 days.
Adverse Effect :
Nausea, vomiting, diarrhea, hypotension, myalgia, ECG changes and myocarditis.
Hepatic Dose :
No dosage adjustments are recommended.