Clioquinol

Mechanism :

Clioquinol is active against a broad spectrum of microorganisms, including fungi (e.g., Candida, Microsporum, Trichophyton) and gram-positive bacteria (e.g., Staphylococci). Clioquinol has only a slight inhibitory effect on gram-negative bacteria. Clioquinol exerts a bacteriostatic, rather than a bactericidal action.

Indication :

• Nonextensive superficial dermatomycoses
• Infected forms of eczema, pyoderma, and mild burns

Contraindications :

Known hypersensitivity to hydroxyquinolines, clioquinol, or other quinoline derivatives, iodine, as well as to any other components of the preparation. Clioquinol should not be used in children under 2 years of age.

Dosing :

Adverse Effect :

Allergic skin reaction

Interaction :

Protein-bound Iodine: Topical use may increase the amount of protein-bound iodine (PBI) in patients with normal thyroid function and therefore may interfere with some thyroid function. These tests should not be performed within a period shorter than 1 month following the use of clioquinol.

Ferric Chloride Test: The ferric chloride test for phenylketonuria may yield a false positive test when trace amounts of clioquinol are present in the urine.

Hepatic Dose :