Question of the Week

Question :

Posted On : 14 Apr 2006

What is physiology and pathogenesis of febrile seizures?

Expert Answer :

No expert answer available.

Answer Discussion :

saeedelsadek

no exact etiology , possibly fever reduces seizure thrshold in susceptible infants.

19 years ago

Febrile seizures have been suspected to have a genetic basis, and recently, mutations in GABAA receptor and sodium channel genes have been identified that are associated with febrile seizures and generalized seizures with febrile seizures plus pedigrees. Pentameric GABAA receptors mediate the majority of fast synaptic inhibition in the brain and are composed of combinations of alpha{1-6}, beta{1-3}, and gamma{1-3} subunits. In alphabetagamma2 GABAA receptors, the gamma2 subunit is critical for receptor trafficking, clustering, and synaptic maintenance, and mutations in the gamma2 subunit have been monogenically associated with autosomal dominant transmission of febrile seizures
GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies.
J Neurosci 2006 Mar, 26{9}:2590-7

19 years ago

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