Question of the Week

Question :
Posted On : 14 Apr 2011
how do we prepare prostaglandin for infusion with respect to dilution , rate of infusion , compatible fluids , and titration
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Expert Answer :
Prostaglandin is usually given by intravenous infusion at a initial dose of 0.05-0.1mcg, k, min. Once the desired effect is attained then the dose is tapered to 0.01-0.025mcg, k, min.

1 ampoule of PGE1 contains 500mcg of drug or 0.5 mg. So if we want to prepare infusion then we add 0.5mg to 50ml syringe prefilled with 50 ml normal saline.

Going by the formula: wt x dose{in mcg, kg, min desired} x 3 { multiplying factor}, amount of drug in 50 ml syringe.

= The rate of infusion.
Answer Discussion :
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