Tigecycline
Mechanism :
Tigecycline is an antibiotic. It works by killing sensitive bacteria.
Indication :
- Safety and efficacy not established in children.
- Multidrug resistant gram-negative bacterial infections.
Contraindications :
Hypersensitivity.
Dosing :
8-11 years:
1.2 mg/kg IV every 12 hours. Max: 50 mg/12 hours.
12-17 years:
50 mg IV every 12 hours.
Adverse Effect :
Dizziness, fever or chills, headache, lower back or side pain, warmth, or burning in the fingers, toes, and legs; painful or difficult urination, problems with vision or hearing.
Rare: Abdominal pain, angioedema, diarrhea, fat in the stool, irregular heartbeat.
Interaction :
Blood Thinners: Some products that may interact with this drug include: "blood thinners" (e.g., warfarin), live bacterial vaccines, retinoid medications taken by mouth (such as acitretin, isotretinoin).
Rifamycins: Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness. This could cause pregnancy. Examples include rifamycins such as rifampin or rifabutin.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Not dialysed. Dose as in normal renal function |
| HD | Not dialysed. Dose as in normal renal function |
| HDF/High flux | Unknown dialysability. Dose as in normal renal function |
| CAV/VVHD | Unknown dialysability. Dose as in normal renal function |
Hepatic Dose :
Mild to moderate hepatic impairment: No dosage adjustment required.
Severe hepatic impairment: Initial dose does not need to be adjusted, maintenance dose is halved.