Tetanus Toxoid
Mechanism :
Clostridium tetani culture is grown in a peptone-based medium containing an extract of bovine muscle tissue and detoxified with formaldehyde. Tetanus Toxoid for intramuscular injection, is a sterile suspension of alum-precipitated toxoid in an isotonic sodium chloride solution.
Indication :
- Tetanus-active protection
- Wounds if last Tetanus vaccine was >5 years ago
Contraindications :
Hypersensitivity to any component of the vaccine, including thimerosal is a contraindication to receipt of Tetanus Toxoid Adsorbed. Contraindicated in case of anaphylaxis or other serious allergic reaction following a previous dose of this vaccine, any other tetanus toxoid-containing vaccine, or any component of this vaccine. Because of uncertainty as to which component of the vaccine may be responsible, no further vaccination with a tetanus component should be carried out.
Dosing :
IM:
0.5 ml.
Adverse Effect :
Redness, warmth, edema, induration with or without tenderness at injection site, urticaria, rash. Malaise, transient fever, pain, hypotension, nausea and arthralgia may develop. Arthus-type hypersensitivity reactions characterized by severe local reactions may occur in persons who have received multiple prior booster doses of a tetanus toxoid-containing vaccine.
Interaction :
Immunosuppressive therapies: May reduce the immune response to vaccines.
Hepatic Dose :
No dosage adjustments are recommended.