Oxaprozin

Mechanism :

Decreases inflammation, pain and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Indication :

• Used in rheumatoid arthritis and osteoarthritis to relieve the inflammation, swelling, stiffness and joint pain.

Contraindications :

Hypersensitivity to aspirin, iodides, or any other NSAID.

Peptic ulcer or other GI diseases, Chronic liver disease, Diabetes mellitus, Pregnancy.

Dosing :

Adverse Effect :

GI effects (bleeding, ulceration, perforation), inhibit platelet aggregation, worsening or precipitation of congenital heart failure along with blood pressure changes, depression, sedation, somnolence, confusion, disturbed sleep, painful urination and decreased urinary frequency, decreased menstrual flow, rash, pruritus, erythema, photosensitivity, visual disturbances, tinnitus, anemia, neutropenia, thrombocytopenia, leukopenia, hepatitis.

Interaction :

Beta-Blockers: Antihypertensive effects may be decreased.
Lithium: May increase lithium levels.
Loop Diuretics: Diuretic effects may be decreased.
Methotrexate: May increase methotrexate levels.
Warfarin: May increase risk of gastric erosion and bleeding.

Hepatic Dose :