Naftifine
Mechanism :
Exhibits antifungal activity by selectively inhibiting the enzyme squalene epoxidase in a dose-dependent manner; has both fungistatic and fungicidal activity.
Indication :
- Tinea infections: Topical treatment of tinea cruris, tinea corporis and tinea pedis.
Contraindications :
Hypersensitivity to naftifine or any component of the formulation.
Dosing :
Tinea corporis, tinea cruris, tinea pedis:
Topical
Cream 1% and gel 1%: Apply once daily (cream) or twice daily (gel) to affected area and surrounding skin for up to 4 weeks.
Adverse Effect :
Burning sensation of skin, xeroderma, skin irritation, erythema, pruritus, application site reaction.
Interaction :
No known significant interactions.
Hepatic Dose :
No dosage adjustments are recommended.