Methyltestosterone
Mechanism :
It is a steroidal male sex hormone, which has anabolic properties and growth of secondary sexual characters in males. It is used in hypogonadism, delayed puberty and hypopituitarism.
Indication :
- Delayed puberty in males
- Hypogonadism in males
Contraindications :
Allergy, Pregnancy, Cancer of prostrate or breast.
Dosing :
10 mg orally every day.
Adverse Effect :
Edema, acne, breast soreness, virilisation and menstrual abnormalities in females; painful penile erections, precocious puberty, cholestatic jaundice, gynaecomastia and hepatic carcinoma. Prolonged administration may cause short stature in children.
Interaction :
Anisindione, Leflunomide, Teriflunomide, Warfarin, Dicumarol.
Hepatic Dose :
Mild and moderate hepatic impairment: Use with caution.
Severe hepatic impairment: Use is contraindicated.
May enhance edema formation which is already present due to hypoalbuminemia in hepatic failure.