Meclizine

Mechanism :

It is an anti-histaminic drug used as an anti-emetic. It has lesser antimuscarinic and lesser sedating properties. It is used to prevent and treat nausea and vomiting associated with motion sickness, Meniere’s disease, sea sickness, vertigo and chronic labyrinthitis.

Indication :

• Nausea/vomiting
• Vertigo
• Motion Sickness

Contraindications :

Renal impairment, Hepatic impairment, IOP increased, Glaucoma, COPD asthma, PUD, Hyperthyroidism, Hypertension, Lower resp. tract SX, GI obstruction, Prostatic hypertrophy, Bladder neck obstruction, High environmental temperature.

Dosing :

Adverse Effect :

Dry mouth, thickened bronchial secretions, constipation, GI upset, urinary retention, drowsiness, Rare: anaphylaxis/anaphylactoid reaction, hemolytic anemia, thrombocytopenia, agranulocytosis, pancytopenia, leukopenia, arrhythmias, seizures, blurred vision, diplopia, tachycardia, photosensitivity, palpitations, diaphoresis, rash, difficulty swallowing, hives.

Interaction :

AVOID:

Cinacalcet; Quinidine; Terbinafine; the Antidepressants Bupropion, Duloxetine, Fluoxetine, Paroxetine, or Sertraline.

Hepatic Dose :