Manganese
Mechanism :
Trace element
Indication :
- Trace element added to parenteral nutrition (PN) to prevent manganese deficiency; orally as a dietary supplement
Contraindications :
Due to its highly acidic pH (pH 2.0), direct IV or IM injection is contraindicated; may result in severe tissue damage.
Dosing :
Parenteral nutrition, maintenance requirement: IV: 2 to 10 mcg/kg/day.
Note: Use caution in premature neonates; manganese chloride solution for injection contains aluminium.
Adverse Effect :
Use with caution in biliary tract or hepatic impairment.
Interaction :
No known interactions.
Hepatic Dose :
Liver and/or biliary tract dysfunction may require omission or reduction of manganese doses
because manganese is primarily eliminated in the bile.