Mafenide
Mechanism :
The exact mechanism of action is unclear. It is bacteriostatic against gram negative and positive organisms. It appears to interfere with bacterial folic acid synthesis.
Indication :
Contraindications :
• Hypersensitivity to any of the components
• Use cautiously in patients with sulfonamide allergy
• Use cautiously in patients with G6PD deficiency
• Prolonged use may cause fungal/bacterial superinfections
• Use cautiously in patients with respiratory insufficiency
• Avoid use in women of childbearing age and in pregnancy unless burned area is more than 20% BSA or if benefits outweigh the risks
Dosing :
Cream:
<2 years: Limited data regarding safety and efficacy.
>2 years: To be applied to clean debrided area once daily or once 12 hourly at 1/16 inch thickness; Burned areas should be covered with cream at all times-apply PRN.
Topical Solution:
Grafted area to be covered with one layer of gauze.
Apply/wrap a wet 8-ply burn dressing with the solution until leakage observed.
Keep gauze dressing wet by irrigating with a syringe or injecting the solution into irrigation tubing every 4 hourly or PRN.
Wound dressing may be left undisturbed for up to 5 days.
Adverse Effect :
Application site local reactions, swelling, pain, excoriations, hypersensitivity, blisters, diarrhea, burning sensation, bone marrow suppression, porphyria, eosinophilia, hemolytic anemia, hyperventilation, systemic acidosis, allergic reactions, anemia
Interaction :
• Allogenic cultured keratinocytes and fibroblasts
• dichlorphenamide
Lactation :
Limited data available regarding drug excretion in breast milk.
Hepatic Dose :
Hepatic dose adjustment has not been defined.
Pregnanacy :
Pregnancy Category C.