Ivabradine
Mechanism :
It is a hyperpolarization activated cyclic nucleotide gated channel blocker. It inhibits the SA node resulting in bradycardia. It block HCN channel responsible for cardiac pacemaker that rgulates heart rate.
Indication :
- Used for symptomatic heart failure
Contraindications :
• Bradycardia
• Bundle branch block
• Hepatic disease
• Driving
• Operating heavy machinery
• Hypotension
Dosing :
Used for symptomatic heart failure:
Infants 6 to 11 months of age:
0.05 mg/kg/dose Per oral twice daily.
Children weighing less than 40 kg:
0.05 mg/kg/dose Per oral twice daily
Children weighing 40 kg or more:
2.5 mg Per oral twice daily.
Interaction :
• Major drug interactions with amiodarone
• Major drug interactions with aprepitant
• Major drug interactions with barbiturates
• Major drug interactions with bosentan
Hepatic Dose :
Contraindicated in patients with hepatic disease