Human Albumin

Albumin

Mechanism :

Albumin is responsible for 70-80% of the colloid osmotic pressure of normal plasma, thus making it useful in regulating the volume of circulating blood. Albumin is also a transport protein and binds naturally occurring, therapeutic and toxic materials in the circulation. The half-life of albumin in plasma is approximately 16 hours, with about 90% of the dose remaining in the intravascular space 2 hours after administration. Although albumin remains in the plasma for 16 hours, it is still found in the body long afterwards. The elimination half-life of albumin from the body is 15 to 20 days.

Indication :

• Replacement Therapy for hypoalbuminemia
• Hypovolemic Shock

Contraindications :

Contraindicated in case of history of allergic reactions to albumin. Also contraindicated in severely anaemic patients and in patients with cardiac failure. Extreme care should be taken in babies with congenital heart defects.

Dosing :

Adverse Effect :

Nausea, fever, chills, urticaria, anaphylaxis, hypertension, bronchospasm, pulmonary edema.

Interaction :

None.

Hepatic Dose :