Fulvestrant

Mechanism :

Fulvestrant is an estrogne receptor antagonist.

Indication :

• Precocious puberty (associated with McCune-Albright syndrome).

Contraindications :

• Use cautiously in patients with thrombocytopenia

• Use cautiously in patients with therapeutic anticoagulation

• Use cautiously in patients with bleeding diathesis

Females of reproductive age should be advised to use contraception.

• Neurologic events

• peripheral neuropathy

• Hepatic disease

Dosing :

Adverse Effect :

Nausea, pain, vasodilation, pharyngitis, constipation, diarrhea, pain in the abdomen, back pain, headache, pyrexia, chest pain, UTI, anemia, edema, cough, anorexia, leukopenia, myalgia, osteoporosis, muscle pain, rash.

Interaction :

• Siponimiod

• Maitake

• Taurine

Hepatic Dose :

Dose adjustment may be needed for hepatic impairment but there are no recommendations regarding this for the paediatric population.