Framycetin Sulphate
Mechanism :
It is a topical aminoglycoside. Framycetin works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth.
Indication :
- Bacterial conjunctivitis, bacterial blepharitis, corneal ulcers, corneal injuries.
- Prophylaxis of ocular infections following foreign body removal.
- ENT infections and burns and scalds.
- Otitis externa
Contraindications :
Hypersensitivity.
Framycetin Sulphate is contraindicated in conditions like Tuberculosis, Viral eye infection, Glaucoma.
Dosing :
Available as ophthalmic solution and cream.
Ophthalmic/Otic drop:
1-2 drops 3-4 times daily. Ointment: Application at bedtime.
Adverse Effect :
Inflammation, irritation, contact dermatitis, burning sensation, stinging, pruritus, ototoxicity, GI symptoms.
Hepatic Dose :
No dosage adjustments are recommended.