Epinastine
Mechanism :
Histamine 1 receptor antagonist, it also prevents the release of histamine from mast cells involved in allergic response; has affinity for H2 alpha1, alpha2, and 5HT2 receptors
Indication :
- To prevent ocular pruritis in allergic conjunctivitis patients.
Dosing :
Children ≥2 years-Instil one drop in each affected eye twice daily.
Remove contact lens before application and wait for 10 mins after application for reinserting the lens.
Adverse Effect :
Ocular- Delayed hyperaemia, irritation, lacrimation
Respiratory system- Sinusitis, pharyngitis, rhinitis, cough
Accidental contamination of ophthalmic solution can cause bacterial keratitis
Lactation :
Unknown if excreted in milk, use with caution
Pregnanacy :
Animal studies show some risk, but no controlled human studies done. It can be used if benefits outweigh the risks