Elamipretide
Mechanism :
Mitochondria-targeting peptide; free radical scavenger and antioxidant that penetrates the cellular and outer mitochondrial membranes, and targets cardiolipin, which is found exclusively in the inner mitochondrial membrane.
Indication :
- Pending FDA approval
- Mitochondrial Myopathies
- Optic Neuropathy
- Leber’s Hereditary Optic Neuropathy
Dosing :
Only for use in children >16 years of age.
0.01-0.25 mg/kg/h IV infusion over 2 hours for 5 days.
Adverse Effect :
Headache, dizziness, abdominal pain, flatulence.
Hepatic Dose :
No data available regarding dosage adjustment.