Cyclizine

Mechanism :

Cyclizine is a piperazine derivative with histamine H1-receptor antagonist (antihistamine) activity. The precise mechanism of action in inhibiting the symptoms of motion sickness is not well understood. It may have effects directly on the labyrinthine apparatus and on the chemoreceptor trigger zone. Cyclizine exerts a central anticholinergic (antimuscarinic) action.

Indication :

• Vomiting
• Motion sickness
• Meniere disease
• Vestibular vertigo

Contraindications :

Cyclizine should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal tract and hepatic disease. Dose reduction may be necessary in renal impairment, in epilepsy and severe heart failure. Cyclizine injection may have a hypertensive effect.

Dosing :

Adverse Effect :

Drowsiness, occasional dry mouth, blurred vision, headache, psychomotor impairment, anti-muscarinic effects such as urinary retention and gastrointestinal disturbance, urticaria, drug rash, tachycardia, restlessness, nervousness, insomnia and hallucinations.

Interaction :

CNS Depressants: There may be additive effects with the co-administration.
Anticholinergic drugs: Side-effects enhanced.
Tricyclics, Antimuscarinics, Anxiolytics and Hypnotics: Increased antimuscarinic and sedative effects.

Renal Dose :

Hepatic Dose :