Colesevelam

Mechanism :

Colesevelam binds with bile acids in the intestine to form an insoluble complex that is eliminated in faeces.

Indication :

• Heterozygous familial hypercholesterolemia

Contraindications :

History of bowel obstruction; serum TG concentrations of more than 500 mg/dL; history of hypertriglyceridemia-induced pancreatitis.

Dosing :

Adverse Effect :

Constipation, cardiovascular toxicity, hypertension, headache, fatigue, hypertriglyceridemia, dyspepsia, diarrhea, nausea, vomiting, increased CRP, influenza, weakness, back pain.

Interaction :

Amiodarone: Bile Acid Sequestrants may decrease the bioavailability of Amiodarone.
Cholic Acid: Bile Acid Sequestrants may decrease the absorption of Cholic Acid.
Corticosteroids (Oral): Bile Acid Sequestrants may decrease the absorption of Corticosteroids.
Estrogen Derivatives (Contraceptive): Bile Acid Sequestrants may decrease the serum concentration of Estrogen Derivatives.
Loop Diuretics: Bile Acid Sequestrants may decrease the absorption of Loop Diuretics.
Nonsteroidal Anti-Inflammatory Agents: Bile Acid Sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents.
Thiazide and Thiazide-Like Diuretics: Bile Acid Sequestrants may decrease the absorption of Thiazide and Thiazide-Like Diuretics.
Vancomycin: Bile Acid Sequestrants may diminish the therapeutic effect of Vancomycin.

Hepatic Dose :