DMSA
Synonym :
Dimercaptosuccinic acid
Mechanism :
It is a heavy metal chelator used in the treatment of lead toxicity.
Indication :
- Lead Poisoning
- Mercury poisoning
- Arsenic poisoning
Contraindications :
Known allergy to DMSA.
Dosing :
Safety and efficacy in infants have not been established.
30 mg/kg/day 8 hourly PO for 5 days and then 20 mg/kg/day 12 hourly PO for 14 days.
Adverse Effect :
Nausea, vomiting, appetite loss, bitter taste in mouth, rash, eutropenia.
Interaction :
None known.
Hepatic Dose :
More frequent monitoring of serum transaminases may be required in patients with a history of liver disease due to the risk of transient increases. No dosage adjustments are recommended.