Edta

Synonym :

Edetate Calcium Disodium

Mechanism :

Edetate Disodium forms chelates with the cations of many divalent and trivalent metals. Because of its affinity for calcium, edetate disodium produces lowering of the serum calcium level during intravenous infusion. Edetate disodium exerts a negative inotropic effect upon the heart.

Indication :

Emergency treatment of hypercalcemia
Ventricular arrhythmias associated with digitalis toxicity
In the treatment for acute and chronic lead poisoning

Contraindications :

Contraindicated in anuric patients and in generalized arteriosclerosis associated with advancing age.

Dosing :

40 mg/kg/day. Maximum dose: 70 mg/kg/day.

Lead poisoning:

Give the first dose of EDTA 4 hours after first dose of dimercaprol.

Adverse Effect :

Nausea, vomiting, diarrhea, numbness, headache, circumoral paresthesia, transient drop in blood pressure, thrombophlebitis, febrile reactions, hyperuricemia, exfoliative dermatitis, anemia, nephrotoxicity, hemorrhagic tendencies.

Interaction :

Additives may be incompatible with the reconstituted solution.

Insulin: Causes hypoglycaemia, don't give with insulin.

Hepatic Dose :

Specific guidelines for dosage adjustments in hepatic impairment are not available.