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Cefpodoxime
Mechanism :
Cefpodoxime proxetil is an orally administered extended spectrum, semi-synthetic antibiotic of the cephalosporin class. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.
Indication :
- Otitis media
- Community acquired pneumonia
- Tonsillitis
- Pharyngitis
- Enteric fever
Contraindications :
Cefpodoxime is contraindicated in patients with a known allergy to cefpodoxime or to the cephalosporin group of antibiotics.
Dosing :
<2 months:
Safety and efficacy not established.
2 months-12 years:
5 mg/kg (Oral) every 12 hours for 5-10 days;
maximum dose:
200 mg/dose.
>12 years:
200 mg (Oral) every 12 hours for 5-10 days.
Adverse Effect :
Colitis, diarrhea, nausea, vomiting, headache and allergic reactions.
Interaction :
Absorption is decreased by antacids and H2 antagonists.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
20-50 | Dose as in normal renal function |
10-20 | Dose as in normal renal function |
<10 | 100–200 mg every 24 hours |
Dose in Patients undergoing Renal Replacement Therapies
CAPD | Not dialysed. Dose as in GFR<10 mL/min |
HD | Dialysed. Dose as in GFR<10 mL/ min |
HDF/High flux | Dialysed. Dose as in GFR<10 mL/ min |
CAV/VVHD | Dialysed. Dose as in normal renal function |
Hepatic Dose :
No dosage adjustments are recommended.