Carbimazole
Mechanism :
It prevents the peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the T3/T4.
Indication :
- Hyperthyroidism
- Diffuse toxic goitre
- Graves’ disease
- Neonatal thyrotoxicosis
Contraindications :
Contraindicated in hyperthyroidism due to nodular goiter and in liver disease.
Dosing :
15 mg/day orally.
Adverse Effect :
Bone marrow suppression causing neutropenia and agranulocytosis, nausea, headache, rashes, pruritus and arthralgia, alopecia, jaundice.
Interaction :
Warfarin: Increased sensitivity to warfarin.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Not dialysed. Dose as in normal renal function |
| HD | Not dialysed. Dose as in normal renal function |
| HDF/High flux | Unknown dialysability. Dose as in normal renal function |
| CAV/VVHD | Unknown dialysability. Dose as in normal renal function |
Hepatic Dose :
Mild to moderate hepatic impairment: Use with caution. If abnormal liver function is discovered, the treatment should be stopped. The half-life may be prolonged due to the liver disorder.
Severe hepatic impairment: Contraindicated.