Calcipotriol
Synonym :
Calcipotriene
Mechanism :
Calcipotriene is a synthetic analog of vitamin D3.
Induces differentiation and suppresses proliferation of keratinocytes.
Indication :
Contraindications :
Contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. It should not be used by patients with demonstrated hypercalcemia or evidence of vitamin D toxicity.
Dosing :
0.005% w/v ointment/scalp solution.
All preparations: Apply to affected area in the morning and evening. Do not apply to face.
6-12 years: Maximum 50 g.
Adolescents >12 years: 75 g.
Adults: 100 g.
Scalp solution: weekly. Maximum: 60 ml.
Adverse Effect :
Contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. It should not be used by patients with demonstrated hypercalcemia or evidence of vitamin D toxicity.
Local irritation, dermatitis, pruritus, erythema and photosensitivity, aggravation of psoriasis.
Hepatic Dose :
No dosage adjustments are recommended.