Benzamphetamine

Mechanism :

Benzphetamine hydrochloride is a sympathomimetic amine with pharmacologic activity like the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure.

Indication :

• Exogenous obesity (short-term)

Contraindications :

Contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hypothyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. Benzphetamine should not be given to patients who are in an agitated state or who have a history of drug abuse. Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. Should not be used concomitantly with other CNS stimulants.

May cause fetal harm when administered to a pregnant woman.

Dosing :

Adverse Effect :

Palpitation, tachycardia, hypertension, cardiomyopathy, overstimulation, restlessness, dizziness, insomnia, tremor, sweating, headache, psychotic episodes, depression following withdrawal of the drug, dryness of the mouth, unpleasant taste, nausea, diarrhea, constipation, urticaria, changes in libido.

Interaction :

Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly within 14 days following use of monoamine oxidase inhibitors. Should not be used concomitantly with other CNS stimulants.
Amphetamines may decrease the hypotensive effect of antihypertensives. Amphetamines may enhance the effects of tricyclic antidepressants.
Urinary alkalinizing agents increase blood levels and decrease excretion of amphetamines. Urinary acidifying agents decrease blood levels and increase excretion of amphetamines.

Hepatic Dose :