Atenolol
Mechanism :
Atenolol is a cardioselective beta-adrenergic receptor blocking agent without membrane stabilizing or intrinsic sympathomimetic activities.
Indication :
Contraindications :
Atenolol is contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure. It should be avoided in asthmatics.
Dosing :
0.5 to 1 mg/kg/day orally; maximum daily dose:
2 mg/kg/day or 100 mg/day.
Adverse Effect :
Tiredness, bradycardia, postural hypotension, precipitation of heart block, intermittent claudication, Raynaud’s phenomena, depression, dizziness, confusion, mood changes, nightmares, hallucinations, paresthesia, vertigo, bronchospasm, hypoglycaemia, purpura, thrombocytopenia.
Interaction :
Calcium channel blockers: Additive effect.
Prostaglandin synthase inhibiting drugs: Decrease the hypotensive effects of beta blockers.
Catecholamine-depleting drugs such as reserpine: Hypotension, marked bradycardia, vertigo, syncopal attacks, or orthostatic hypotension.
Haloperidol: Hypotension and cardiac arrest.
Theophylline: Clearance is reduced.
Cimetidine: Increasing blood levels.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Not dialysed. Dose as in normal renal function |
| HD | Dialysed. Dose as in normal renal function |
| HDF/High flux | Dialysed. Dose as in normal renal function |
| CAV/VVHD | Dialysed. Dose as in normal renal function |
Hepatic Dose :
No dosage adjustments are recommended.