Almotriptan
Indication :
- Acute Migraine in children >12 years of age.
Dosing :
>12 years: 6.25-12.5 mg orally at onset of headache. Can repeat after 2 hours. Max dose: 25 mg/day.
Adverse Effect :
Increased sleepiness, dizziness, dry mouth, vomiting, paresthesia, anaphylaxis, blurring of vision.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 30-50 | Dose as in normal renal function |
| 10-30 | 6.25 mg; maximum daily dose 12.5 mg. Use with caution |
| <10 | 6.25 mg; maximum daily dose 12.5 mg. Use with caution |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Unknown dialysability. Dose as in GFR<10 mL/min |
| HD | Likely dialysability. Dose as in GFR<10 mL/min |
| HDF/High flux | Likely dialysability. Dose as in GFR<10 mL/min |
| CAV/VVHD | Unknown dialysability. Dose as in GFR=10–30 mL/min |
Hepatic Dose :
Mild to moderate hepatic impairment: Use with caution. Approximately 45% of almotriptan elimination is through hepatic metabolism. The recommended initial dose is 6.25 mg PO; the maximum dosage is 12.5 mg/day.
Severe hepatic impairment: Use is contraindicated.