Short stature

Author: Naji Ahmed

Question
A 14 years old girl presented with short stature. Weight is 44kg {25th centile}, length is 144cm {below 3rd centile}. Past medical history reveals affection with alopecia and vitiligo for which she received lengthy courses of steroid. Now she is off steroids. She has dysmenorrhea. Thyroid function tests are normal. There is no anemia and renal function tests are normal. LH is 1ml U, ml, FSH is 2.4ml U, ml, Prolactin is 9ng, ml, Progesterone is 4nmol, l, and Estradiol is 128pmol, l. No clinical evidence of Turners syndrome. Ultrasound shows follicular cyst in left ovary. Uterus and right ovary is normal. Bone age is depicted in figure 1.

A 14 years old girl presented with short stature. Weight is 44kg {25th centile}, length is 144cm {below 3rd centile}. Past medical history reveals affection with alopecia and vitiligo for which she received lengthy courses of steroid. Now she is off steroids. She has dysmenorrhea. Thyroid function tests are normal. There is no anemia and renal function tests are normal. LH is 1ml U, ml, FSH is 2.4ml U, ml, Prolactin is 9ng, ml, Progesterone is 4nmol, l, and <a class='interlink' href='/drugs/estradiol/822'>Estradiol</a> is 128pmol, l. No clinical evidence of Turners syndrome. Ultrasound shows follicular cyst in left ovary. Uterus and right ovary is normal. Bone age is depicted in figure 1.<br></table>

How can I manage her_?

Answer Discussion :

Dr prakash nagar

check for GH. bone age is not clear so difficult to comment. May be effect of sterod, GH def , or Autoimmune Polyglandular syndrome. First investigate on this line.

12 years ago

Hany EGYcas

more investigation needed like
chromosomal study
GH
possible diagnosis autoimmune polyglandular endocrineopathy
may treated with antiestrogen treatment

12 years ago

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Short stature

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